Regenerative medicine offers hope for treating degenerative and genetic diseases. One of its main goals is to repair damaged tissues by developing ways to transplant pluripotent or multipotent stem cells, which have the ability to transform into many different types of cells. We can improve knee, shoulder and hips chronic pain with the use of mesenchymal stem cells. The most important cause of knee pain is osteoarthritis and well discuss its pathogenesis and how we can interv